Background: In middle-income countries, costs limit widespred use of left ventricular assist device (LVAD) as a strategy for end-stage heart failure.We aim to describe the experience of a LVAD program in a middle-income country in a hub-and-spoke model.Methods: Patients fulfilling strict inclusion and exclusion criteria were referred from different

The force developed by actively lengthened muscle depends on different structures across different scales of lengthening.For small perturbations, the active response of muscle is well captured by a linear-time-invariant (LTI) system: a stiff spring in parallel with a light damper.The force response of muscle to longer stretches is better represente

Boot Box The paths opened by technology have brought the possibility of exploring new scales and inaugurated a new way of understanding Nature from the Nanotechnology.Developed through an ultrasophisticated technoscientific apparatus, it makes the reflection about its infinite reaches and risks be driven by the uncertainty of the scientific models

Summary: Integrating data across heterogeneous research environments is a key challenge in multi-site, collaborative research projects.While it is important to allow for natural variation in data collection protocols across research sites, it is also important to achieve interoperability between datasets in order to reap the Ice Bucket full benefit